Cellulose Acetate Phthalate
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Cellulose Acetate Phthalate
Nonproprietary Names:
Cellulose Acetate Phthalate
Synonyms:
CAP or Cellacefate or Cellacephate or Cellulose Acetate 1,2 – Benzene Dicarboxylate.
Chemical Name & CAS No.
Cellulose Acetate Phthalate; [9004-38-0]
Specifications:
| Properties | Specification | |
| Typical value | BP/USP/EP | |
| Identification | Conforms | |
| Appearance of Film | Conforms | |
| Sulphated Ash | 0.04% | Max 0.1% |
| Residue on Ignition | 0.06% | —– |
| Heavy metals | Conforms | Max 10 ppm |
| Organic volatile impurities | Conforms | |
| Viscosity @25°C | 74 cps | 45 – 90 cps |
| Free Acid | 1.1% | NMT 3% |
| Water | 1.6% | NMT 5% |
| Phthaloyl groups | 34% | 30% to 36% |
| Acetyl groups | 23.5% | 21.5% to 26% |
Physical form :
Powder/Flakes.
Properties :
CAP withstands itself in acidic media in stomach. But it readily dissolves in slight alkaline medium of small intestine.
It is available in BP/USP/NF/EP and IP grades.
Applications :
1. Film coating of tablets
2. Enteric coating of tablets
3. Sustained release
4. Delayed release
5. Pallate coating material
Advantages of film coating :
▪️ Enhance palatability by masking unpleasant tastes or objectionable odours
▪️ Ease ingestion/swallowing
▪️ Improve product appearance
▪️ Protect tablets from light, oxidation & moisture
▪️ Advance the perception of superior product efficacy